The spread of antibiotic resistance, a growing threat to global health that causes millions of deaths annually, is typically blamed on the overuse of drugs in hospitals and in the food industry. However, a new study published in Nature Microbiology suggests that normal geological processes could be accelerating the development of new resistances.

Soil microorganisms naturally produce antibiotics as a form of chemical warfare to compete with each other. When soils dry out, these natural compounds become more concentrated because there is less water to dilute them. Like a dosage increase, this concentration can create a harsher environment, killing sensitive microbes and sparing those with the capacity to resist. This phenomenon, in turn, is an evolutive driver that favors the appearance of new and more effective resistance genes.

To test whether this mechanism is having real genetic effects, Xiaoyu Shan, a microbial ecologist and postdoctoral researcher at the California Institute of Technology (Caltech), and colleagues looked at soil samples under controlled conditions as the samples transitioned from a wet state to a desiccated one. They found that as the soil dried, the presence of genes related to antibiotic production and resistance spiked, suggesting that drought leads to a rapid escalation in the subterranean biological arms race. Importantly, they did not look for pathogenic bacteria specifically, only for resistance genes, which can be present in a variety of microbes, whether those microbes are pathogenic or not.

“Drought leads to this elevation of antibiotic producers and bacteria that are resistant,” said team member Dianne Newman, a professor of biology and geobiology also at Caltech. “It’s a pretty simple idea: If you have more antibiotics in your environment, only the organisms that can withstand it…can resist it.”

Alternative Explanations

However, there could be other potential explanations for the observed increase in antibiotic-producing and antibiotic resistance genes, according to Enrique Monte, a microbiologist at the Universidad de Salamanca in Spain who wasn’t involved with the new study. For instance, arid soils are naturally more diverse than humid soils, making it common to find a more diverse gene pool in the ground, Monte said. In addition, the mere presence of antibiotic genes might not result in an actual release to the environment, or a release could happen in dosages that are too small to cause noticeable effects. “There are antibiotics that are volatile; they escape into the air, so they never reach a therapeutic concentration to kill others,” Monte said.

The authors, however, took some precautions to show that the increase in antibiotic resistance genes was actually a biological response to environmental stress. For instance, they also tracked other genes that should remain unaffected or decline under desiccation. As expected, genes that are needed for basic survival remained stable, while genes responsible for bacterial movement declined in dry soil, where mobility is restricted. Even some species that were not favored by desiccation saw an increase in resistance-related genes, “which is even stronger evidence,” Shan said.

Geographic Limitations

As the researchers combed through publicly available metagenomic data libraries, they had to select collections with strict control of all variables and in which the only changing factor was water content. That limited the analysis to five locations: two grasslands and a sorghum field in California; a forest in Valais, Switzerland; and a wetland in Nanchang, China.

The scarcity of locations might limit how extrapolable these results are, said Fiona Walsh, a microbiologist at Maynooth University in Ireland who was not involved with the work. “There are thousands of high-quality metagenomes available online with excellent metadata. I would really like to see a comparison where they apply their analysis to a broader map of global metagenomic data to see if they reach the same conclusions,” she said.

From the Soil to the Hospital

The study also suggests that dry soils might be a hidden driver of clinical cases of antibiotic resistance worldwide. The authors combined hospital data on the number of cases of resistant infections from 116 countries with the local aridity index, which measures temperature and precipitation, for each location. They found a strong correlation: Drier regions consistently showed a higher number of resistant bacteria cases in hospitals, even after adjusting for confounding factors such as local income.

However, the authors admitted that this is only a correlation effect and doesn’t prove causation. “It motivates follow-up research to see how environmental concentration weighs against human overuse and poor stewardship,” Newman said.

Even this correlation could be a stretch, according to microbiologist Sara Soto, head of the Global Viral and Bacterial Infections Programme at the Instituto de Salud Global de Barcelona. At the end of the day, she said, the authors have soil data from only five locations in three countries, and they are not tracking the specific bacterial varieties that make people sick, only resistance genes.

For the thesis to be solid, Soto said, the ideal approach would have been to contrast hospital strains from a specific area with soil data from that same region during the same drought episode. “Making such a vast inference—that what happens in the soil of one location affects what happens in a hospital elsewhere—is a big leap,” she said.

The authors, however, point out that resistance genes from soils can eventually make their way into human pathogens. Microbes have the capacity to share genetic material across species—a process known as horizontal gene transfer. In their analysis, the team identified specific resistance sequences that appeared to have been transferred between soil bacteria relatively recently, perhaps within the past decade. How they are reaching hospitals remains a matter for a future study, they said.

As droughts increase in numerous regions in the face of climate change, this selective pressure within soil ecosystems is expected to intensify. Though these findings do not show that drought directly puts drug-resistant pathogens in hospitals, they still suggest that a drying climate could set the scene for an increase in antibiotic resistance, the researchers report.

—Javier Barbuzano (@javibar.bsky.social), Science Writer

Citation: Barbuzano, J. (2026), Antibiotic resistance might get a boost from droughts, Eos, 107, https://doi.org/10.1029/2026EO260132. Published on 29 April 2026.

Text © 2026. The authors. CC BY-NC-ND 3.0
Except where otherwise noted, images are subject to copyright. Any reuse without express permission from the copyright owner is prohibited.

Lead-acid batteries are omnipresent. An integral part of most electric vehicles and all conventional vehicles globally, they also serve as backup energy storage systems in developing countries. But if lead-acid batteries are recycled in smelting units without adequate pollution control measures, they can cause elevated lead pollution that persists in local soils for thousands of years. However, because recycling sites with pollution control measures cost millions of dollars, most efforts are informal and unregulated.

In a recent study, researchers reported that scraping lead-contaminated soil in the vicinity of an abandoned recycling site for used lead-acid batteries and treating it with phosphate was linked to a 22% reduction in the blood lead levels (BLLs) of children who were living close to that site in a Bangladeshi town. The research was published in the International Journal of Hygiene and Environmental Health.

“Informal battery recycling is rampant in Bangladesh,” said study coauthor Mahbubur Rahman, an environmental health scientist at the International Centre for Diarrhoeal Disease Research, Bangladesh. “Used lead-acid batteries are broken up and smelted in close proximity to residential and agricultural areas, which exposes those communities to lead emissions that contaminate their soil and water sources.”

Rahman and colleagues analyzed the BLLs of 130 children living close to two recycling sites for used lead-acid batteries (ULAB) in the Tangail District of Bangladesh that were abandoned in early 2019. They also assessed the BLLs of 37 children who did not live anywhere near ULAB recycling sites. The researchers then carried out soil remediation efforts at one of the ULAB sites but not the other. Prior to the work, the team members held informational sessions for the community about the dangers of lead pollution so locals could provide informed consent to participate.

The team observed that following remediation efforts, the lead content of the soil in and around the former battery recycling site decreased from more than 20,000 parts per million to less than 400 parts per million, which was considered acceptable by the U.S. EPA when the study was conducted, from 2022 to 2023. (The EPA reduced the limit to 200 parts per million in 2024.)

The researchers collected and cleaned up soil from children’s play areas, roadsides, and courtyards of 68 households that belonged to the intervention group. A year after the lead-contaminated soil was cleaned up, the 89 children from those households had the most significant decreases in their BLLs: from 90.1 to 70.4 micrograms per liter, a decrease of more than 21%.

The children in the group who lived close to the second abandoned ULAB recycling site, where soil remediation was not conducted, experienced only about an 8.4% decrease in their BLLs, from 88.5 to 81.1 micrograms per liter. The reduction in the control group’s BLLs could be attributed to a government initiative focused on reducing lead levels in turmeric, which was happening over the same time period as the study, Rahman said.

Anne Riederer, an environmental health scientist at the University of Washington who was not involved in the new study, said the dangers of lead exposure from ULAB recycling sites are well documented.

“We know for sure that the areas close to abandoned ULAB recycling sites are as contaminated as areas around abandoned lead mines. This study fits with the bigger picture of what we have learned to date about cleaning up contaminated sites and how that could improve children’s health,” she said.

A Widespread Issue

Similar studies conducted in Brazil and Bangladesh reported 46% and 35% reductions, respectively, in children’s BLLs following soil remediation initiatives around ULAB recycling sites.

Despite those drastic improvements, the children’s BLLs were still far above the World Health Organization’s threshold of 50 micrograms per liter. “This could mean there are other sources of lead exposure, like paints and cookware items,” said Rahman. “Or the persistently high BLLs could be because of chronic and long-term lead exposure, due to which lead gets deposited deep into the bones for several decades, even if [people] move away from toxic sites.”

“The reason why this issue is so widespread is [that] informal recycling is cheap,” he said. “That makes the formal sector reluctant to invest in costly pollution control measures.”

—Anuradha Varanasi, Science Writer

Citation: Varanasi, A. (2026), Cleanup of battery recycling sites may lower childhood lead exposure, Eos, 107, https://doi.org/10.1029/2026EO260120. Published on 15 April 2026.

Text © 2026. The authors. CC BY-NC-ND 3.0
Except where otherwise noted, images are subject to copyright. Any reuse without express permission from the copyright owner is prohibited.